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Von Hippel-Lindau disease is a genetic condition due to mutation of the Von Hippel-Lindau gene, which leads to an increased risk in the development of hemangioblastomas of the brain and spinal cord. The pathophysiology of disease and its clinical manifestations, as they pertain to the general neurologist, are discussed. Therapeutic management of central nervous system hemangioblastomas ranging from neurosurgical resection, radiation therapy, and systemic therapies is reviewed. |
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ataxic gait
brainstem,neoplasms of
cerebellar hemangioma
cyst
cyst, peritumoral
cyst,neoplastic cerebellum
gene
gene mutation
genetic counselling
genetic neurologic disorders
headache
hemangioblastoma
hematuria,gross
intracranial pressure,increased
MRI,abnormal
MRI,contrast enhanced
nausea and vomiting
neoplasm,metastatic to CNS
neoplasm,primary of CNS
neoplasm,primary of CNS-surgical treatment of
pheochromocytoma
radiation therapy,CNS treatment and complications with
radiation therapy,stereotactic
retinal hemangioma
review article
spinal cord,neoplasm
stereotaxic surgery
treatment of neurologic disorder
Von Hippel Lindau
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